Details of Drug Interaction

Details of Drug-Drug Interaction

 Drug General Information (ID: DDIU1A0Y83)
  Drug Name Triamterene Drug Info Nefazodone Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Diuretics Antidepressants
  Structure

 Mechanism of Triamterene-Nefazodone Interaction (Severity Level: Moderate)
     Additive hypotensive effects Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Triamterene Nefazodone
      Mechanism Antihypertensive agent
Amiloride-sensitive sodium channel  Blocker 		Potentiate the hypotensive effect of antihypertensive agents
      Key Mechanism Factor 1
Factor Name Amiloride-sensitive sodium channel Structure Sequence
Protein Family Amiloride-sensitive sodium channel (TC 1.A.6) family
Protein Function
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands. Also plays a role in taste perception.
    Click to Show/Hide
      Mechanism Description
  • Additive hypotensive effects by the combination of Triamterene and Nefazodone 

Recommended Action
      Management Caution and close monitoring for altered efficacy and safety are recommended if patients receive nefazodone with agents that can produce significant hypotension such as antihypertensive agents or vasodilators. Patients should be made aware of the possible side effects (e.g., dizziness, lightheadedness, orthostasis) and be cautioned about driving, operating machinery, or performing other hazardous tasks.

References
1 Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
2 Product Information. Serzone (nefazodone). Bristol-Myers Squibb, Princeton, NJ.
3 Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]