Drug General Information (ID: DDITWG0D7Y)
Drug Name			Exemestane		Drug Info		Estramustine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antineoplastics				Antineoplastics
Structure

Mechanism of Exemestane-Estramustine Interaction (Severity Level: Moderate)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Exemestane				Estramustine
Mechanism		Aromatase inhibitor				Decrease the therapeutic effect of aromatase inhibitor
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Exemestane when combined with Estramustine

Recommended Action
Management		Use of estrogen-containing products should be avoided during aromatase inhibitor therapy.

References
1	Product Information. Aromasin (exemestane) Pharmacia &amp Upjohn, Kalamazoo, MI.
2	Product Information. Femara (letrozole). Novartis Pharmaceuticals, East Hanover, NJ.
3	Product Information. Arimidex (anastrozole). Zeneca Pharmaceuticals, Wilmington, DE.