Drug General Information (ID: DDITS5H8C1)
Drug Name			Paramethadione		Drug Info		Apomorphine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anticonvulsants				Dopaminergic Antiparkinsonism Agents
Structure

Mechanism of Paramethadione-Apomorphine Interaction (Severity Level: Moderate)
Additive CNS depression effects Click to Show/Hide Mechanism Graph
Drug Name		Paramethadione				Apomorphine
Mechanism		CNS depression effects				CNS depression effects
Key Mechanism Factor 1
		Factor Name		CNS depression effects
		Factor Description		CNS depressants are drugs that inhibit or suppress brain activity and can reduce mental and physical processes. Excessive CNS depression can lead to decreased heart rate, slow breathing (less than 10 breaths per minute), extreme confusion or loss of memory, nausea and vomiting, poor judgment, blue lips or fingertips, irritability and aggression, and clammy or cold skin.
Mechanism Description		Additive CNS depression effects by the combination of Paramethadione and Apomorphine

Recommended Action
Management		The use of other sedating drugs should generally be avoided during apomorphine treatment. Patients prescribed these agents concurrently should be monitored for potentially excessive or prolonged CNS depression, especially if they are elderly or debilitated. Ambulatory patients should be made aware of the possibility of additive CNS effects (e.g., drowsiness, dizziness, lightheadedness, confusion) and counseled to avoid activities requiring mental alertness until they know how these agents affect them.

References
1	Product Information. Apokyn (apomorphine). Mylan Pharmaceuticals Inc, Morgantown, WV.
2	Product Information. Zohydro ER (HYDROcodone). Zogenix, Inc, San Diego, CA.