Drug General Information (ID: DDITP19QXD)
  Drug Name Torasemide Drug Info Carboplatin Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Diuretics Antineoplastics
  Structure

 Mechanism of Torasemide-Carboplatin Interaction (Severity Level: Moderate)
     Increased risk of ototoxicity Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Torasemide Carboplatin
      Mechanism Ototoxicity Ototoxicity
      Key Mechanism Factor 1
Factor Name Ototoxicity
Factor Description Ototoxicity is the damage to the organs of hearing and/or balance following exposure to drugs or chemicals that affect the inner ear. Ototoxic drugs can impair hearing, balance, or both.
      Mechanism Description
  • Increased risk of ototoxicity by the combination of Torasemide and Carboplatin 

Recommended Action
      Management It is recommended to regularly monitor auditory function if concomitant use is necessary. Patients should be advised to promptly notify their physician if they experience hearing loss or tinnitus.

References
1 Langer T, am Zehnhoff-Dinnesen A, Radtke S, Meitert J, Zolk O "Understanding platinum-induced ototoxicity." Trends Pharmacol Sci 34 (2013): 458-69. [PMID: 23769626]
2 Product Information. Edecrin (ethacrynic acid). Merck &amp Co, Inc, West Point, PA.
3 Product Information. Paraplatin (carboplatin). Bristol-Myers Squibb, Princeton, NJ.