Drug General Information (ID: DDITMZK5RL)
Drug Name			Tuberculin purified protein derivative		Drug Info		Isatuximab		Drug Info
Drug Type		Allergenics				Monoclonal antibody
Therapeutic Class		Allergy Test				Antineoplastics/Cd38 Monoclonal Antibodies

Mechanism of Tuberculin purified protein derivative-Isatuximab Interaction (Severity Level: Moderate)
Diminish the response to diagnostic skin test antigens Click to Show/Hide Mechanism Graph
Drug Name		Tuberculin purified protein derivative				Isatuximab
Mechanism		Diagnostic skin test antigens				Immunosuppressive effects
Key Mechanism Factor 1
		Factor Name		Diagnostic skin test antigens
		Factor Description		The efficacy of diagnostic skin test antigens may be reduced, leading to falsely insignificant or false-negative results may occur in such patients.
Mechanism Description		Reduced reactions to diagnostic skin test antigens for Tuberculin purified protein derivative when combined with Isatuximab

Recommended Action
Management		Clinicians should be aware of the potential for falsely insignificant or false-negative results when administering diagnostic skin test antigens to patients treated with immunosuppressive agents.

References
1	Product Information. Tuberculin PPD (Mantoux) (tuberculin purified protein derivative). Connaught Laboratories Ltd, Toronto, ON.
2	Product Information. Candin (candida albicans extract). Nielsen Biosciences Inc, San Diego, CA.
3	Product Information. Spherulin (coccidioidin skin test). ALK Laboratories Inc, Wallingford, CT.