Drug General Information (ID: DDITIZJ5O6)
Drug Name			Diroximel fumarate		Drug Info		Trastuzumab deruxtecan		Drug Info
Drug Type		Small molecule				Monoclonal antibody
Therapeutic Class		Selective Immunosuppressants				Antineoplastics/Her2 Inhibitors

Mechanism of Diroximel fumarate-Trastuzumab deruxtecan Interaction (Severity Level: Moderate)
Additive immunosuppressive effects Click to Show/Hide Mechanism Graph
Drug Name		Diroximel fumarate				Trastuzumab deruxtecan
Mechanism		Immunosuppressive effects				Immunosuppressive effects
Key Mechanism Factor 1
		Factor Name		Immunosuppressive effects
		Factor Description		Immunosuppression is when your immune system is not functioning as it should. The immune system is made up of cells, tissues and organs that help the body fight off infections. If the immune system is suppressed, an infection that your body was able to control may become serious or even fatal.
Mechanism Description		Additive immunosuppressive effects by the combination of Diroximel fumarate and Trastuzumab deruxtecan

Recommended Action
Management		The safety and efficacy of monomethyl fumarate, dimethyl fumarate, or diroximel fumarate in combination with other immunosuppressive or myelosuppressive agents have not been evaluated. Until further information is available, concomitant use should be avoided if possible.

References
1	Product Information. Vumerity (diroximel fumarate). Alkermes, Inc, Cambridge, MA.