Details of Drug-Drug Interaction
| Drug General Information (ID: DDITI82W4Z) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Drug Name | Mefloquine | Drug Info | Propranolol | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Antimalarial Agents | Antianxiety Agents | |||||||
| Structure | |||||||||
| Mechanism of Mefloquine-Propranolol Interaction (Severity Level: Moderate) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Increased risk of bradycardia Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Mefloquine | Propranolol | |||||||
| Mechanism | Bradycardia | Bradycardia | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Bradycardia | ||||||||
| Factor Description | Bradycardia is a slow heart rate in which the heart beats less than 60 times per minute. If the heart rate is very slow and the heart is not pumping enough oxygen-rich blood to the body, and you may feel dizzy, very tired or weak, and short of breath. | ||||||||
| Mechanism Description |
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| Recommended Action | |||||||||
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| Management | Clinical monitoring is advisable for patients receiving this combination. The potential risk to patients with heart disease should be weighed against the expected benefits of mefloquine treatment. | ||||||||
| References | |||||||||||||||||||
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| 1 | Product Information. Lariam (mefloquine). Roche Laboratories, Nutley, NJ. | ||||||||||||||||||