Drug General Information (ID: DDITBSWNHR)
Drug Name			Furosemide		Drug Info		Chloral hydrate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Diuretics				Anxiolytics/Sedatives/Hypnotics
Structure

Mechanism of Furosemide-Chloral hydrate Interaction (Severity Level: Moderate)
Competitive binding of plasma proteins Click to Show/Hide Mechanism Graph
Drug Name		Furosemide				Chloral hydrate
Mechanism		Competition for plasma protein binding sites				Competition for plasma protein binding sites
Key Mechanism Factor 1
		Factor Name		Plasma protein binding
		Factor Description		Plasma protein binding refers to the degree of binding of a drug to proteins in the blood, and the lower the degree of binding, the more efficiently the drug can cross cell membranes or diffuse. Plasma protein binding alters the distribution and therapeutic characteristics of the drugs.
Mechanism Description		Increased plasma concentration of Chloral hydrate and Furosemide due to competitive binding of plasma proteins

Recommended Action
Management		The manufacturer recommends avoiding concomitant therapy. Consider using an alternative hypnotic drug in patients who require intravenous furosemide.

References
1	Cerner Multum, Inc "ANVISA Bulario Eletrnico.".
2	Cerner Multum, Inc. "Australian Product Information.".
3	Cerner Multum, Inc. "Canadian Product Information.".
4	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
5	Pevonka MP, Yost RL, Marks RG, Howell WS, Stewart RB "Interaction of chloral hydrate and furosemide: a controlled retrospective study." Drug Intell Clin Pharm 11 (1977): 332-5.
6	Product Information. Lasix (furosemide). sanofi-aventis , Bridgewater, NJ.
7	Scappaticci KA, Ham JA, Sohn YJ, Miller RD, Dretchen KL "Effects of furosemide on the neuromuscular junction." Anesthesiology 57 (1982): 381-8. [PMID: 6291433]