Drug General Information (ID: DDIT9MDWB1)
Drug Name			Arformoterol		Drug Info		Naphazoline (ophthalmic)		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Bronchodilators				Antineoplastics
Structure

Mechanism of Arformoterol-Naphazoline (ophthalmic) Interaction (Severity Level: Moderate)
Additive hypertensive effects Click to Show/Hide Mechanism Graph
Drug Name		Arformoterol				Naphazoline (ophthalmic)
Mechanism 1		Hypertensive effects				Hypertensive effects
Key Mechanism Factor 1
		Factor Name		Hypertensive effects
		Factor Description		Hypertension is defined as a blood pressure reading above a prescribed limit (130/90 mmHg). Most people with hypertension have no signs or symptoms; others may experience: severe headache, shortness of breath, nosebleeds, severe anxiety, and feeling a tingling sensation in the neck or head.
Mechanism Description		Additive hypertensive effects by the combination of Arformoterol and Naphazoline (ophthalmic)
Increased risk of rapid heart rate Click to Show/Hide Mechanism Graph
Drug Name		Arformoterol				Naphazoline (ophthalmic)
Mechanism 2		Tachycardia				Tachycardia
Key Mechanism Factor 2
		Factor Name		Tachycardia
		Factor Description		A faster-than-normal heart rate, but the heart is beating normally. Tachycardia may not cause any symptoms or complications, but if left untreated, some forms of tachycardia can lead to serious health problems, including heart failure, stroke, or sudden cardiac death.
Mechanism Description		Increased risk of rapid heart rate by the combination of Arformoterol and Naphazoline (ophthalmic)

Recommended Action
Management		Caution is advised if beta-2 adrenergic agonists are used concomitantly with other adrenergic agents, particularly in patients with cardiovascular disorders such as coronary insufficiency, cardiac arrhythmias, hypertrophic obstructive cardiomyopathy, or hypertension. Blood pressure and heart rate should be closely monitored.

References
1	Lowe MD, Rowland E, Brown MJ, Grace AA "Beta(2) adrenergic receptors mediate important electrophysiological effects in human ventricular myocardium." Heart 86 (2001): 45-51. [PMID: 11410561]
2	Product Information. Breo Ellipta (fluticasone-vilanterol). GlaxoSmithKline, Research Triangle Park, NC.
3	Product Information. Brovana (arformoterol). Sepracor Inc, Marlborough, MA.