Drug General Information (ID: DDISXGTCA2)
Drug Name			Alendronic acid		Drug Info		Selenium		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Bone Density Conservation Agents				Minerals And Electrolytes
Structure

Mechanism of Alendronic acid-Selenium Interaction (Severity Level: Moderate)
Complex formation Click to Show/Hide Mechanism Graph
Drug Name		Alendronic acid				Selenium
Mechanism		Binds to polyvalent cations				Polyvalent cations
Key Mechanism Factor 1
		Factor Name		Chelation
		Factor Description		Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
Mechanism Description		Decreased absorption of Selenium due to formation of complexes caused by Alendronic acid

Recommended Action
Management		Antacids or other oral medications containing aluminum, calcium, magnesium and other polyvalent cations should be administered at least 30 minutes after the bisphosphonate dose.

References
1	Product Information. Bonefos (clodronate). Rhone-Poulenc Rorer Canada Inc, Laval, QC.
2	Product Information. Boniva (ibandronate). Roche Laboratories, Nutley, NJ.
3	Product Information. Skelid (tilundronate). Sanofi Winthrop Pharmaceuticals, New York, NY.