Drug General Information (ID: DDISMQI8ED)
Drug Name			Peginterferon alfa-2a		Drug Info		Palifermin		Drug Info
Drug Type		Interferons				Protein/peptide
Therapeutic Class		Antineoplastics				Antimucositis Agents

Mechanism of Peginterferon alfa-2a-Palifermin Interaction (Severity Level: Moderate)
Additive immunosuppressive effects Click to Show/Hide Mechanism Graph
Drug Name		Peginterferon alfa-2a				Palifermin
Mechanism		Immunosuppressive effects				Immunomodulatory effects (fibroblast growth factor)
Key Mechanism Factor 1
		Factor Name		Immunosuppressive effects
		Factor Description		Immunosuppression is when your immune system is not functioning as it should. The immune system is made up of cells, tissues and organs that help the body fight off infections. If the immune system is suppressed, an infection that your body was able to control may become serious or even fatal.
Mechanism Description		Additive immunosuppressive effects by the combination of Palifermin and Peginterferon alfa-2a

Recommended Action
Management		Palifermin should not be administered within 24 hours before, during infusion of, or within 24 hours after administration of myelotoxic chemotherapy.

References
1	Product Information. Kepivance (palifermin). Shire US Inc, Florence, KY.