Details of Drug Interaction

Details of Drug-Drug Interaction

 Drug General Information (ID: DDISLFUA7K)
  Drug Name Flavoxate Drug Info Metoclopramide Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Parasympatholytics Antiemetics
  Structure

 Mechanism of Flavoxate-Metoclopramide Interaction (Severity Level: Moderate)
     Antagonize the effect of cholinergic agents Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Flavoxate Metoclopramide
      Mechanism Anticholinergic effects
Muscarinic acetylcholine receptor  Antagonist 		Cholinergic effects
Dopamine receptor  Antagonist
      Key Mechanism Factor 1
Factor Name Muscarinic acetylcholine receptor M Structure Sequence
Protein Family G-protein coupled receptor 1 family
Protein Function
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
    Click to Show/Hide
      Key Mechanism Factor 2
Factor Name Dopamine receptor Structure Sequence
Protein Family G-protein coupled receptor 1 family
Protein Function
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
    Click to Show/Hide
      Mechanism Description
  • Antagonize the effect of Metoclopramide when combined with Flavoxate 

Recommended Action
      Management Concomitant use of gastrointestinal prokinetic agents with anticholinergic agents should be avoided, if possible.

References
1 Product Information. Motilium (domperidone). Janssen-Ortho Inc, Toronto, ON.
2 Product Information. Reglan (metoclopramide). Wyeth-Ayerst Laboratories, Philadelphia, PA.