Drug General Information (ID: DDISH50GX1)
Drug Name			Metyrosine		Drug Info		Lurasidone		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antineoplastics				Atypical Antipsychotics
Structure

Mechanism of Metyrosine-Lurasidone Interaction (Severity Level: Moderate)
Increased risk of other adverse reactions (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Metyrosine				Lurasidone
Mechanism		Extrapyramidal effects				Extrapyramidal effects
Key Mechanism Factor 1
		Factor Name		Adverse reactions
		Factor Description		An adverse reaction is an unexpected negative reaction to a medication or treatment that happens even when it's used correctly.
Mechanism Description		Increased risk of adverse reactions by the combination of Metyrosine and Lurasidone

Recommended Action
Management		When concurrent use is required, patients should be monitored for extrapyramidal symptoms and instructed to notify their physician if they experience symptoms such as bradykinesia, hypertonia, rigidity, restlessness, and dysphagia. Patients should also avoid driving or operating hazardous machinery until they know how the medications affect them.

References
1	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
2	Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
3	Product Information. Demser (metyrosine). Merck &amp Co, Inc, West Point, PA.