Details of Drug Interaction

Details of Drug-Drug Interaction

 Drug General Information (ID: DDISCL6B7M)
  Drug Name Apomorphine Drug Info Guanethidine Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Dopaminergic Antiparkinsonism Agents Antihypertensive Agents
  Structure

 Mechanism of Apomorphine-Guanethidine Interaction (Severity Level: Moderate)
     Additive hypotensive effects Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Apomorphine Guanethidine
      Mechanism 1 Antihypertensive agent Antihypertensive agent
Adrenergic neuron  Blocker
      Key Mechanism Factor 1
Factor Name Hypotensive effects
Factor Description Hypotension is a blood pressure reading below the prescribed limit (90/60 mmHg). Symptoms of hypotension may include: blurred or faded vision , dizziness or light-headedness, fainting , fatigue , difficulty concentrating, nausea.
      Mechanism Description
  • Additive hypotensive effects by the combination of Apomorphine and Guanethidine 
      Mechanism 2 Hypotensive effects Antihypertensive agent
Adrenergic neuron  Blocker
      Key Mechanism Factor 2
Factor Name Hypotensive effects
Factor Description Hypotension is a blood pressure reading below the prescribed limit (90/60 mmHg). Symptoms of hypotension may include: blurred or faded vision , dizziness or light-headedness, fainting , fatigue , difficulty concentrating, nausea.
      Mechanism Description
  • Additive hypotensive effects by the combination of Apomorphine and Guanethidine 

Recommended Action
      Management Caution and close monitoring for altered efficacy and safety are recommended if patients receive apomorphine with an antihypertensive agent or vasodilator. Patients should be made aware of the possible side effects (e.g., dizziness, lightheadedness, orthostasis) and be cautioned about driving, operating machinery, or performing other hazardous tasks. They should also be advised to avoid rising abruptly from a sitting or recumbent position and to contact their physician if they experience symptoms of hypotension such as dizziness, lightheadedness, or fainting.

References
1 Bailey DG, Dresser GK "Natural products and adverse drug interactions." Can Med Assoc J 170 (2004): 1531-2. [PMID: 15136542]
2 Ho PC, Ghose K, Saville D, Wanwimolruk S "Effect of grapefruit juice on pharmacokinetics and pharmacodynamics of verapamil enantiomers in healthy volunteers." Eur J Clin Pharmacol 56 (2000): 693-8. [PMID: 11214778]
3 Product Information. Apokyn (apomorphine). Mylan Pharmaceuticals Inc, Morgantown, WV.