Drug General Information (ID: DDISC9F4PH)
Drug Name			Chloroquine		Drug Info		Vibrio cholerae CVD 103-HgR strain live antigen (live)		Drug Info
Drug Type		Small molecule				Vaccine
Therapeutic Class		Antimalarial Agents				Vaccines

Mechanism of Chloroquine-Vibrio cholerae CVD 103-HgR strain live antigen (live) Interaction (Severity Level: Major)
Antagonize the effect of vaccine/toxoid Click to Show/Hide Mechanism Graph
Drug Name		Chloroquine				Vibrio cholerae CVD 103-HgR strain live antigen (live)
Mechanism		Impairs immunomodulatory bacterial infective agent				Immunomodulatory infective agent
Key Mechanism Factor 1
		Factor Name		Vaccine/toxoid
		Factor Description		The beneficial effects of the vaccine/toxinoid may be reduced, leading to a diminished or suboptimal immune response.
Mechanism Description		Antagonize the effect of Chloroquine when combined with Vibrio cholerae CVD 103-HgR strain live antigen (live)

Recommended Action
Management		Live, attenuated cholera vaccine should not be administered with chloroquine. The manufacturer recommends that the vaccine be administered at least 10 days before beginning antimalarial prophylaxis with chloroquine.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Product Information. Vaxchora (cholera vaccine, live). PaxVax, Miami, FL.
3	Kollaritsch H, Que JU, Kunz C, Wiedermann G, Herzog C, Cryz SJ Jr "Safety and immunogenicity of live oral cholera and typhoid vaccines administered alone or in combination with antimalarial drugs, oral polio vaccine, or yellow fever vaccine." J Infect Dis 175 (1997): 871-5.[PMID: 9086143]