Details of Drug Interaction

Details of Drug-Drug Interaction

 Drug General Information (ID: DDISBM0D1Y)
  Drug Name Minoxidil Drug Info Nesiritide Drug Info
  Drug Type Small molecule Hormones
  Therapeutic Class Antihypertensive Agents Recombinant Natriuretic Peptide
  Structure

 Mechanism of Minoxidil-Nesiritide Interaction (Severity Level: Moderate)
     Additive hypotensive effects Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Minoxidil Nesiritide
      Mechanism Antihypertensive agent
ATP-sensitive inward rectifier potassium channel  Inducer 		Antihypertensive agent
Guanylate cyclase  Agonist
      Key Mechanism Factor 1
Factor Name Inward rectifier potassium channel Structure Sequence
Protein Family Inward rectifier-type potassium channel (TC 1.A.2.1) family
Protein Function
This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium (By similarity). Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.
    Click to Show/Hide
      Key Mechanism Factor 2
Factor Name Guanylate cyclase soluble Structure Sequence
Protein Family Adenylyl cyclase class-4/guanylyl cyclase family
Protein Function
There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms. Activated by nitric oxide in the presence of magnesium or manganese ions.
    Click to Show/Hide
      Mechanism Description
  • Additive hypotensive effects by the combination of Minoxidil and Nesiritide 

Recommended Action
      Management Whether used alone or with other agents, nesiritide should be administered only in settings where blood pressure can be closely monitored. The dosage should be reduced or the drug discontinued in patients who develop hypotension.

References
1 Product Information. Natrecore (nesiritide) Scios Inc, Sunnyvale, CA.