Details of Drug Interaction | MecDDI

Drug General Information (ID: DDIRWAS584)
Drug Name			Triamterene		Drug Info		Zaleplon		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Diuretics				Anxiolytics/Sedatives/Hypnotics
Structure

Mechanism of Triamterene-Zaleplon Interaction (Severity Level: Moderate)
Additive hypotensive effects Click to Show/Hide Mechanism Graph

Drug Name		Triamterene				Zaleplon
Mechanism 1		Antihypertensive agent Amiloride-sensitive sodium channel Blocker				Antihypertensive agent
Key Mechanism Factor 1
		Factor Name		Amiloride-sensitive sodium channel				Structure Sequence
		Protein Family		Amiloride-sensitive sodium channel (TC 1.A.6) family
		Protein Function		Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands. Also plays a role in taste perception. Click to Show/Hide
Mechanism Description		Additive hypotensive effects by the combination of Triamterene and Zaleplon
Mechanism 2		Antihypertensive agent Amiloride-sensitive sodium channel Blocker				Hypotensive effects
Key Mechanism Factor 2
		Factor Name		Amiloride-sensitive sodium channel				Structure Sequence
		Protein Family		Amiloride-sensitive sodium channel (TC 1.A.6) family
		Protein Function		Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands. Also plays a role in taste perception. Click to Show/Hide
Mechanism Description		Additive hypotensive effects by the combination of Triamterene and Zaleplon

Recommended Action
Management		Caution and close monitoring for development of hypotension is advised during coadministration of these agents. Avoid alcohol in patients receiving vasodilating antihypertensive drugs. Patients should be advised to avoid rising abruptly from a sitting or recumbent position and to notify their physician if they experience dizziness, lightheadedness, syncope, orthostasis, or tachycardia.

References
1	Ellison JM, Milofsky JE, Ely E "Fluoxetine-induced bradycardia and syncope in two patients." J Clin Psychiatry 51 (1990): 385-6. [PMID: 2211552]
2	Feder R "Bradycardia and syncope induced by fluoxetine." J Clin Psychiatry 52 (1991): 139. [PMID: 2005082]
3	Sternbach H "Fluoxetine-associated potentiation of calcium-channel blockers." J Clin Psychopharmacol 11 (1991): 390-1. [PMID: 1770159]