Drug General Information (ID: DDIRW1VDCK)
Drug Name			Strontium chloride Sr-89		Drug Info		Calcium lactate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Therapeutic Radiopharmaceuticals				Minerals And Electrolytes
Structure

Mechanism of Strontium chloride Sr-89-Calcium lactate Interaction (Severity Level: Moderate)
Interference of cell/tissue uptake Click to Show/Hide Mechanism Graph
Drug Name		Strontium chloride Sr-89				Calcium lactate
Mechanism		Strontium-89 chloride				Reduce uptake of strontium-89 chloride by bone
Key Mechanism Factor 1
		Factor Name		Pharmacokinetics
		Factor Description		Alters the distribution of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Interference of cell/tissue uptake of Strontium chloride Sr-89 by Calcium lactate

Recommended Action
Management		Calcium-containing preparations should be withheld for 2 weeks before until 2 weeks after administration of strontium-89 chloride.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Davies NT "Anti-nutrient factors affecting mineral utilization." Proc Nutr Soc 38 (1979): 121-8. [PMID: 88737]
3	Multum Information Services, Inc. Expert Review Panel.