Drug General Information (ID: DDIRVEHCD4)
Drug Name			Octreotide		Drug Info		Indium In-111 pentetreotide		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Somatostatin/Somatostatin Analogs				Diagnostic Radiopharmaceuticals
Structure

Mechanism of Octreotide-Indium In-111 pentetreotide Interaction (Severity Level: Moderate)
Interference of cell/tissue uptake Click to Show/Hide Mechanism Graph
Drug Name		Octreotide				Indium In-111 pentetreotide
Mechanism		Reduction of indium-111 pentapeptide accumulation in tumors				Indium In-111 pentetreotide
Key Mechanism Factor 1
		Factor Name		Pharmacokinetics
		Factor Description		Alters the distribution of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Interference of cell/tissue uptake of Indium In-111 pentetreotide by Octreotide

Recommended Action
Management		Consideration should be given to temporarily suspending somatostatin analog therapy prior to the administration of indium In-111 pentetreotide. Patients should be monitored for any signs of withdrawal.

References
1	Product Information. Sandostatin (octreotide). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
2	Product Information. Somatuline Depot (lanreotide). Ipsen Inc, Milford, MA.
3	Product Information. Octreoscan (indium pentetreotide In-111). Mallinckrodt Medical Inc, St. Louis, MO.