Drug General Information (ID: DDIRTK298M)
Drug Name			Rotavirus vaccine		Drug Info		Candida albicans		Drug Info
Drug Type		Vaccine				Allergenics
Therapeutic Class		Vaccine				Allergy Test

Mechanism of Rotavirus vaccine-Candida albicans Interaction (Severity Level: Moderate)
Diminish the response to diagnostic skin test antigens Click to Show/Hide Mechanism Graph
Drug Name		Rotavirus vaccine				Candida albicans
Mechanism		Vaccine or toxoid				Diagnostic skin test antigens
Key Mechanism Factor 1
		Factor Name		Diagnostic skin test antigens
		Factor Description		The efficacy of diagnostic skin test antigens may be reduced, leading to falsely insignificant or false-negative results may occur in such patients.
Mechanism Description		Reduced reactions to diagnostic skin test antigens for Candida albicans when combined with Rotavirus vaccine

Recommended Action
Management		Clinicians should be aware of the potential for falsely insignificant or false-negative results when performing delayed-hypersensitivity skin testing on patients who have recently received live virus vaccines. Diagnostic skin test antigens should be administered before, simultaneously with, or 4 to 6 weeks after immunization.

References
1	Product Information. Tuberculin PPD (Mantoux) (tuberculin purified protein derivative). Connaught Laboratories Ltd, Toronto, ON.
2	Product Information. Multitest CMI (skin test antigens, multiple). Aventis Pharmaceuticals, Swiftwater, PA.
3	Product Information. MSTA Mumps Skin Test Antigen (mumps skin test antigen). Aventis Pharmaceuticals, Swiftwater, PA.