Drug General Information (ID: DDIRSPO2G0)
Drug Name			Iopanoic acid		Drug Info		Iothalamic acid		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Diagnostic Agents				Ionic Iodinated Contrast Media
Structure

Mechanism of Iopanoic acid-Iothalamic acid Interaction (Severity Level: Moderate)
Increased risk of nephrotoxicity Click to Show/Hide Mechanism Graph
Drug Name		Iopanoic acid				Iothalamic acid
Mechanism		Nephrotoxicity				Nephrotoxicity
Key Mechanism Factor 1
		Factor Name		Nephrotoxicity
		Factor Description		The combination of drugs that can induce nephrotoxicity may increase the risk of kidney injury. When kidney injury occurs, the inability to remove excess urine and waste from the body can lead to high levels of urea nitrogen, creatinine, and electrolytes (such as potassium and magnesium) in the blood.
Mechanism Description		Increased risk of nephrotoxicity by the combination of Iopanoic acid and Iothalamic acid

Recommended Action
Management		Administration of any intravascular contrast agent should be deferred for 48 hours in patients with hepatic or biliary disorders who have recently received an oral cholecystographic contrast agent.

References
1	Product Information. Ultravist (iopromide). Berlex, Richmond, CA.
2	Product Information. Visipaque (iodixanol). Nycomed Inc, Princeton, NJ.
3	Product Information. Omniscan (gadodiamide). Novation, Irving, TX.