Drug General Information (ID: DDIRP576G8)
Drug Name			Iron		Drug Info		Dexlansoprazole		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Iron Supplement				Proton Pump Inhibitors
Structure

Mechanism of Iron-Dexlansoprazole Interaction (Severity Level: Moderate)
Altered gastric pH Click to Show/Hide Mechanism Graph
Drug Name		Iron				Dexlansoprazole
Mechanism		Gastric pH sensitive				Gastric alkalinizer
Key Mechanism Factor 1
		Factor Name		Gastric pH
		Factor Description		The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs.
Mechanism Description		Decreased absorption of Iron due to altered gastric pH caused by Dexlansoprazole

Recommended Action
Management		Patients with iron deficiency may not respond adequately to oral iron replacement therapy during coadministration of proton pump inhibitors. If an interaction is suspected after ruling out other causes, it may be appropriate to discontinue the proton pump inhibitor or consider administering iron parenterally.

References
1	Hutchison C, Geissler CA, Powell JJ, Bomford A "Proton pump inhibitors suppress absorption of dietary non-haem iron in hereditary haemochromatosis." Gut 56 (2007): 1291-5. [PMID: 17344278]
2	Product Information. Kapidex (dexlansoprazole). Takeda Pharmaceuticals America, Lincolnshire, IL.
3	Product Information. Prilosec (omeprazole). Merck &amp Co, Inc, West Point, PA.