Drug General Information (ID: DDIR8GWAOF)
Drug Name			Dulaglutide		Drug Info		Calaspargase pegol		Drug Info
Drug Type		Protein/peptide				Monoclonal antibody
Therapeutic Class		Antidiabetic Agents				Antineoplastics

Mechanism of Dulaglutide-Calaspargase pegol Interaction (Severity Level: Moderate)
Antagonize the effect of antidiabetic agents Click to Show/Hide Mechanism Graph
Drug Name		Dulaglutide				Calaspargase pegol
Mechanism 1		Antidiabetic agent				Hyperglycemia
Key Mechanism Factor 1
		Factor Name		Antidiabetic agents
		Factor Description		The hypoglycemic effect of antidiabetes may be reduced, leading to higher blood glucose, increased blood glucose fluctuations, and the possibility of hyperglycemic complications
Mechanism Description		Antagonize the effect of Dulaglutide when combined with Calaspargase pegol
Mechanism 2		Antidiabetic agent				Hyperglycemic effects
Key Mechanism Factor 2
		Factor Name		Antidiabetic agents
		Factor Description		The hypoglycemic effect of antidiabetes may be reduced, leading to higher blood glucose, increased blood glucose fluctuations, and the possibility of hyperglycemic complications
Mechanism Description		Antagonize the effect of Dulaglutide when combined with Calaspargase pegol

Recommended Action
Management		Close clinical monitoring of glycemic control is recommended following initiation or discontinuation of these drugs, and the dosages of concomitant antidiabetic agents adjusted as necessary. Patients should be advised to notify their physician if their blood glucose is consistently high or if they experience symptoms of severe hyperglycemia such as excessive thirst and increases in the volume or frequency of urination.

References
1	Jori A, Carrara MC "On the mechanism of the hyperglycaemic effect of chlorpromazine." J Pharm Pharmacol 18 (1966): 623-4. [PMID: 4381950]
2	Product Information. Dymelor (acetohexamide) Lilly, Eli and Company, Indianapolis, IN.
3	Product Information. Thorazine (chlorpromazine). SmithKline Beecham, Philadelphia, PA.