Details of Drug Interaction

Drug General Information (ID: DDIR15MEP2)
Drug Name		Alosetron	Drug Info		Procainamide	Drug Info
Drug Type	Small molecule			Small molecule
Therapeutic Class	Gastrointestinal Agents			Antiarrhythmic Agents
Structure

Mechanism of Alosetron-Procainamide Interaction (Severity Level: Minor)
Non-CYP450 enzyme inhibition Click to Show/Hide Mechanism Graph

Drug Name	Alosetron		Procainamide
Mechanism	N-acetyltransferase inhibitor		N-acetyltransferase substrate
Key Mechanism Factor 1
	Factor Name	N-acetyltransferase		Structure Sequence
	Protein Family	Arylamine N-acetyltransferase family
	Protein Function	Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens. Click to Show/Hide
Mechanism Description	Decreased metabolism of Procainamide caused by Alosetron mediated inhibition of non-CYP450 enzyme

References
1	Product Information. Lotronex (alosetron). Glaxo Wellcome, Research Triangle Park, NC.

Details of Drug-Drug Interaction