Drug General Information (ID: DDIQZ73UVR)
Drug Name			Fluphenazine		Drug Info		Meropenem		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antipsychotic Agents				Antibiotics
Structure

Mechanism of Fluphenazine-Meropenem Interaction (Severity Level: Moderate)
Increased risk of lowers seizure threshold Click to Show/Hide Mechanism Graph
Drug Name		Fluphenazine				Meropenem
Mechanism		Lower seizure threshold				Lower seizure threshold
Key Mechanism Factor 1
		Factor Name		Lowers seizure threshold
		Factor Description		The combination of medications that lower the seizure threshold is a factor that makes people with epilepsy more likely to have seizures. A seizure is a sudden, uncontrolled electrical disturbance in the brain that can cause changes in your behavior, movements or sensations, and level of consciousness.
Mechanism Description		Increased risk of lowers seizure threshold by the combination of Fluphenazine and Meropenem

Recommended Action
Management		Caution is advised if fluphenazine is administered with any substance that can reduce the seizure threshold, particularly in the elderly and in patients with epilepsy, a history of seizures, or other risk factors for seizures (e.g., head trauma, brain tumor, metabolic disorders, alcohol and drug withdrawal, CNS infections). Ambulatory patients should be counseled to avoid hazardous activities requiring mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".