Details of Drug Interaction

Details of Drug-Drug Interaction

 Drug General Information (ID: DDIQVRTSJC)
  Drug Name Digoxin Drug Info Metoclopramide Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antiarrhythmic Agents Antiemetics
  Structure

 Mechanism of Digoxin-Metoclopramide Interaction (Severity Level: Minor)
     Altered gastrointestinal dynamics Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Digoxin Metoclopramide
      Mechanism Absorption is influenced by gastrointestinal motility Increase gastrointestinal motility
      Key Mechanism Factor 1
Factor Name Gastrointestinal Motility
Factor Description Gastrointestinal motility is an important factor in determining the absorption of orally administered drugs, and it controls the residence time of the drug in the digestive tract.
      Mechanism Description
  • Altered absorption of Digoxin due to GI dynamics variation caused by Metoclopramide 

References
1 Fraser EJ, Leach RH, Poston JW, Bold AM, Culank LS, Lipede AB "Dissolution-rates and bioavailability of digoxin tablets." Lancet 1 (1973): 1393. [PMID: 4122785]
2 Greiff JMC, Rowbotham D "Pharmacokinetic drug interactions with gastrointestinal motility modifying agents." Clin Pharmacokinet 27 (1994): 447-61. [PMID: 7882635]
3 Johnson BF, Bustrack JA, Urbach DR, Hull JH, Marwaha R "Effect of metoclopramide on digoxin absorption from tablets and capsules." Clin Pharmacol Ther 36 (1984): 724-30. [PMID: 6499354]
4 Johnson BF, O'Grady J, Bye C "The influence of digoxin particle size on absorption of digoxin and the effect of propantheline and metoclopramide." Br J Clin Pharmacol 5 (1978): 465-7. [PMID: 656287]
5 Kirch W, Janisch HD, Santos SR, Duhrsen U, Dylewicz P, Ohnhaus EE "Effect of cisapride and metoclopramide on digoxin bioavailability." Eur J Drug Metab Pharmacokinet 11 (1986): 249-50. [PMID: 3582418]
6 Manninen V, Apajalahti A, Melin J, Karesoja M "Altered absorption of digoxin in patients given propantheline and metoclopramide." Lancet 1 (1973): 398-400. [PMID: 4119707]
7 Manninen V, Apajalahti A, Simonen H, Reissell P "Effect of propantheline and metoclopramide on absorption of digoxin." Lancet 1 (1973): 1118-9. [PMID: 4122033]
8 Medin S, Nyberg L "Effect of propantheline and metoclopramide on absorption of digoxin." Lancet 1 (1973): 1393. [PMID: 4122784]
9 Product Information. Lanoxicaps (digoxin). Glaxo Wellcome, Research Triangle Park, NC.