Drug General Information (ID: DDIQSZUNR6)
Drug Name			Entacapone		Drug Info		Iron		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiparkinson Agents				Iron Supplement
Structure

Mechanism of Entacapone-Iron Interaction (Severity Level: Moderate)
Complex formation Click to Show/Hide Mechanism Graph
Drug Name		Entacapone				Iron
Mechanism		Binds to polyvalent cations				Polyvalent cations
Key Mechanism Factor 1
		Factor Name		Chelation
		Factor Description		Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
Mechanism Description		Decreased absorption of Iron due to formation of complexes caused by Entacapone

Recommended Action
Management		Patients receiving entacapone concomitantly with iron-containing products should be advised to separate the times of administration by 2 to 3 hours.

References
1	Product Information. Comtan (entacapone) Novartis Pharmaceuticals, East Hanover, NJ.
2	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
3	Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]