Drug General Information (ID: DDIQN53WJT)
Drug Name			Digoxin		Drug Info		Bretylium		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiarrhythmic Agents				Antiarrhythmic Agents
Structure

Mechanism of Digoxin-Bretylium Interaction (Severity Level: Moderate)
Increased risk of other adverse reactions (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Digoxin				Bretylium
Mechanism		Digoxin				Exacerbate digoxin toxicity and digoxin-induced arrhythmias
Key Mechanism Factor 1
		Factor Name		Adverse reactions
		Factor Description		An adverse reaction is an unexpected negative reaction to a medication or treatment that happens even when it's used correctly.
Mechanism Description		Increased risk of adverse reactions by the combination of Digoxin and Bretylium

Recommended Action
Management		Bretylium should be used cautiously in patients on digoxin and should be avoided if digitalis toxicity is present. Simultaneous initiation of therapy should also be avoided.

References
1	Darcy PF "Nutrient-drug interactions." Adverse Drug React Toxicol Rev 14 (1995): 233-54. [PMID: 8845456]
2	Heissenbuttel RH, Bigger JT Jr "Bretylium tosylate: a newly available antiarrhythmic drug for ventricular arrhythmias." Ann Intern Med 91 (1979): 229-38
3	Product Information. Bretylol (bretylium). DuPont Pharmaceuticals, Wilmington, DE.