Drug General Information (ID: DDIQH8PUWS)
Drug Name			Quinapril		Drug Info		Ferrous sulfate anhydrous		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antihypertensive Agents				Iron Supplement
Structure

Mechanism of Quinapril-Ferrous sulfate anhydrous Interaction (Severity Level: Moderate)
Complex formation Click to Show/Hide Mechanism Graph
Drug Name		Quinapril				Ferrous sulfate anhydrous
Mechanism		Polyvalent cations (magnesium hydroxide excipient)				Binds to polyvalent cations
Key Mechanism Factor 1
		Factor Name		Chelation
		Factor Description		Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
Mechanism Description		Decreased absorption of Quinapril due to formation of complexes caused by Ferrous sulfate anhydrous

Recommended Action
Management		The manufacturer does not make a specific recommendation, but generally the administration of these drugs and magnesium-containing products should be separated by at least two to three hours.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Multum Information Services, Inc. Expert Review Panel.
3	Ray K, Dorman S, Watson R "Severe hyperkalaemia due to the concomitant use of salt substitutes and ACE inhibitors in hypertension: a potentially life threatening interaction." J Hum Hypertens 13 (1999): 717-20. [PMID: 10516744]