Details of Drug Interaction

Details of Drug-Drug Interaction

 Drug General Information (ID: DDIQH6L2VI)
  Drug Name Echothiophate (ophthalmic) Drug Info Neostigmine Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Ophthalmic Glaucoma Agents Parasympathomimetics
  Structure

 Mechanism of Echothiophate (ophthalmic)-Neostigmine Interaction (Severity Level: Moderate)
     Additive cholinergic effects Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Echothiophate (ophthalmic) Neostigmine
      Mechanism Cholinergic effects
Acetylcholinesterase  Inhibitor 		Cholinergic effects
Acetylcholinesterase  Inhibitor
      Key Mechanism Factor 1
Factor Name Acetylcholinesterase
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Structure Sequence
MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPEDPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGYEIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQYVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKNQFDHYSKQDRCSDL
Gene Name ACHE
Uniprot ID ACES_HUMAN
KEGG Pathway hsa:43
Protein Family Type-B carboxylesterase/lipase family
Protein Function
Hydrolyzes rapidly the acetylcholine neurotransmitter released into the synaptic cleft allowing to terminate the signal transduction at the neuromuscular junction. Role in neuronal apoptosis.
    Click to Show/Hide
      Mechanism Description
  • Additive cholinergic effects by the combination of Echothiophate (ophthalmic) and Neostigmine 

Recommended Action
      Management Patients should be monitored for excessive cholinergic effects and worsening of myasthenic symptoms.

References
1 Product Information. Phospholine Iodide (echothiophate iodide ophthalmic). Wyeth Laboratories, Philadelphia, PA.