Details of Drug-Drug Interaction
| Drug General Information (ID: DDIQF63XI2) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Drug Name | Ranitidine (bismuth citrate) | Drug Info | Selpercatinib | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Antiulcer Agents | Antineoplastics | |||||||
| Structure | |||||||||
| Mechanism of Ranitidine (bismuth citrate)-Selpercatinib Interaction (Severity Level: Major) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Altered gastric pH Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Ranitidine (bismuth citrate) | Selpercatinib | |||||||
| Mechanism | Gastric alkalinizer | Gastric pH sensitive | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Gastric pH | ||||||||
| Factor Description | The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs. | ||||||||
| Mechanism Description |
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| Recommended Action | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Management | Concomitant use of selpercatinib with H2-receptor antagonists should generally be avoided. If coadministration is required, the manufacturer recommends taking selpercatinib 2 hours before or 10 hours after the H2 receptor antagonist to minimize the clinical impact of the interaction. | ||||||||
| References | |||||||||||||||||||
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| 1 | Product Information. Retevmo (selpercatinib). Lilly, Eli and Company, Indianapolis, IN. | ||||||||||||||||||