Drug General Information (ID: DDIQ8FLC4W)
Drug Name			Levothyroxine		Drug Info		Quinapril		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antithyroid Agents				Antihypertensive Agents
Structure

Mechanism of Levothyroxine-Quinapril Interaction (Severity Level: Moderate)
Complex formation Click to Show/Hide Mechanism Graph
Drug Name		Levothyroxine				Quinapril
Mechanism		Binds to polyvalent cations				Polyvalent cations (magnesium hydroxide excipient)
Key Mechanism Factor 1
		Factor Name		Chelation
		Factor Description		Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
Mechanism Description		Decreased absorption of Quinapril due to formation of complexes caused by Levothyroxine

Recommended Action
Management		The manufacturer does not make a specific recommendation, but generally the administration of these drugs and magnesium-containing products should be separated by at least two to three hours.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Multum Information Services, Inc. Expert Review Panel.