Drug General Information (ID: DDIQ734BC0)
Drug Name			Ranitidine		Drug Info		Ledipasvir		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiulcer Agents				Antiviral Agents
Structure

Mechanism of Ranitidine-Ledipasvir Interaction (Severity Level: Moderate)
Altered gastric pH Click to Show/Hide Mechanism Graph
Drug Name		Ranitidine				Ledipasvir
Mechanism		Gastric alkalinizer				Gastric pH sensitive
Key Mechanism Factor 1
		Factor Name		Gastric pH
		Factor Description		The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs.
Mechanism Description		Decreased absorption of Ledipasvir due to altered gastric pH caused by Ranitidine

Recommended Action
Management		H2-receptor antagonists may be administered simultaneously with or 12 hours apart from ledipasvir-sofosbuvir at a dose that does not exceed the equivalent of famotidine 40 mg twice daily.

References
1	Product Information. Harvoni (ledipasvir-sofosbuvir). Gilead Sciences, Foster City, CA.