Drug General Information (ID: DDIPMR4CSY)
Drug Name			Olopatadine (nasal)		Drug Info		Zaleplon		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiallergic Agents				Anxiolytics/Sedatives/Hypnotics
Structure

Mechanism of Olopatadine (nasal)-Zaleplon Interaction (Severity Level: Moderate)
Additive CNS depression effects Click to Show/Hide Mechanism Graph
Drug Name		Olopatadine (nasal)				Zaleplon
Mechanism		CNS depression effects				CNS depression effects
Key Mechanism Factor 1
		Factor Name		CNS depression effects
		Factor Description		CNS depressants are drugs that inhibit or suppress brain activity and can reduce mental and physical processes. Excessive CNS depression can lead to decreased heart rate, slow breathing (less than 10 breaths per minute), extreme confusion or loss of memory, nausea and vomiting, poor judgment, blue lips or fingertips, irritability and aggression, and clammy or cold skin.
Mechanism Description		Additive CNS depression effects by the combination of Olopatadine (nasal) and Zaleplon

Recommended Action
Management		Concomitant use of olopatadine nasal spray with alcohol or other CNS depressants should generally be avoided if possible. In the event that they are used together, patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their doctor if they experience excessive or prolonged CNS effects that interfere with their normal activities.

References
1	Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
2	Product Information. Patanase (olopatadine nasal). Alcon Laboratories Inc, Fort Worth, TX.
3	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.