Drug General Information (ID: DDIPJU986X)
Drug Name			Dulaglutide		Drug Info		Clobetasol (topical)		Drug Info
Drug Type		Protein/peptide				Small molecule
Therapeutic Class		Antidiabetic Agents				Antiinflammatory Agents

Mechanism of Dulaglutide-Clobetasol (topical) Interaction (Severity Level: Minor)
Antagonize the effect of antidiabetic agents Click to Show/Hide Mechanism Graph
Drug Name		Dulaglutide				Clobetasol (topical)
Mechanism 1		Antidiabetic agent				Hyperglycemia
Key Mechanism Factor 1
		Factor Name		Antidiabetic agents
		Factor Description		The hypoglycemic effect of antidiabetes may be reduced, leading to higher blood glucose, increased blood glucose fluctuations, and the possibility of hyperglycemic complications
Mechanism Description		Antagonize the effect of Dulaglutide when combined with Clobetasol (topical)
Mechanism 2		Antidiabetic agent				Hyperglycemic effects
Key Mechanism Factor 2
		Factor Name		Antidiabetic agents
		Factor Description		The hypoglycemic effect of antidiabetes may be reduced, leading to higher blood glucose, increased blood glucose fluctuations, and the possibility of hyperglycemic complications
Mechanism Description		Antagonize the effect of Dulaglutide when combined with Clobetasol (topical)

References
1	Seale JP, Compton MR "Side-effects of corticosteroid agents." Med J Aust 144 (1986): 139-42. [PMID: 3511355]
2	Product Information. Psorcon (diflorasone topical). Rhone-Poulenc Rorer, Collegeville, PA.
3	Pace WE "Topical corticosteroids." Can Med Assoc J 108 (1973): 11 passim. [PMID: 4682644]