Drug General Information (ID: DDIPJKVZ41)
Drug Name			Methotrexate		Drug Info		Sodium acetate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antimetabolites				Minerals And Electrolytes
Structure

Mechanism of Methotrexate-Sodium acetate Interaction (Severity Level: Minor)
Altered urine pH Click to Show/Hide Mechanism Graph
Drug Name		Methotrexate				Sodium acetate
Mechanism		Urine pH sensitive				Urine alkalinizer
Key Mechanism Factor 1
		Factor Name		Urine pH
		Factor Description		The normal range of urine pH is between 4.5 and 8, depending mainly on the hydrogen ion concentration. Changes in urine pH may significantly affect drug reabsorption and excretion.
Mechanism Description		Altered elimination of Methotrexate caused by Sodium acetate mediated altered urine pH

References
1	Nirenberg A, Mosende C, Mehta BM, Gisolfi AL, Rosen G "High-dose methotrexate with citrovorum factor rescue: predictive value of serum methotrexate concentrations and corrective measures to avert toxicity." Cancer Treat Rep 61 (1977): 779-83. [PMID: 302143]
2	Sand TE, Jacobsen S "Effect of urine pH and flow on renal clearance of methotrexate." Eur J Clin Pharmacol 19 (1981): 453-6. [PMID: 7250179]
3	Stoller RG, Hande KR, Jacobs SA, Rosenberg SA, Chabner BA "Use of plasma pharmacokinetics to predict and prevent methotrexate toxicity." N Engl J Med 297 (1977): 630-4. [PMID: 302412]