Drug General Information (ID: DDIPIEB2N5)
Drug Name			Duloxetine		Drug Info		Ranitidine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antidepressants				Antiulcer Agents
Structure

Mechanism of Duloxetine-Ranitidine Interaction (Severity Level: Minor)
Altered gastric pH Click to Show/Hide Mechanism Graph
Drug Name		Duloxetine				Ranitidine
Mechanism		Gastric pH sensitive				Gastric alkalinizer
Key Mechanism Factor 1
		Factor Name		Gastric pH
		Factor Description		The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs.
Mechanism Description		Decreased absorption of Duloxetine due to altered gastric pH caused by Ranitidine

References
1	Product Information. Cymbalta (duloxetine). Lilly, Eli and Company, Indianapolis, IN.