Drug General Information (ID: DDIPF570ZY)
Drug Name			Chloroquine		Drug Info		Methsuximide		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antimalarial Agents				Anticonvulsants
Structure

Mechanism of Chloroquine-Methsuximide Interaction (Severity Level: Moderate)
Antagonize the effect of antiepileptic agents Click to Show/Hide Mechanism Graph
Drug Name		Chloroquine				Methsuximide
Mechanism		Lower seizure threshold				Antiepileptic agent
Key Mechanism Factor 1
		Factor Name		Antiepileptic agents
		Factor Description		The beneficial effects of antiepileptic drugs may be reduced, leading to an increase in seizure frequency or duration.
Mechanism Description		Antagonize the effect of Methsuximide when combined with Chloroquine

Recommended Action
Management		The potential risks and benefits should be evaluated prior to initiating chloroquine or hydroxychloroquine in patients on anticonvulsant therapy. In addition, patients with a history of epilepsy should be advised about the risk of chloroquine/hydroxychloroquine-induced seizures. alternative anti-malarial agents may be required. Local treatment guidelines should be consulted.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	Product Information. Aralen (chloroquine). Sanofi Winthrop Pharmaceuticals, New York, NY.
4	Product Information. Hydroxychloroquine Sulfate (hydroxychloroquine). Prasco Laboratories, Cincinnati, OH.
5	Product Information. Plaquenil (R). (hydroxychloroquine). Sanofi Winthrop Pharmaceuticals, New York, NY.