Drug General Information (ID: DDIPAIB6EX)
  Drug Name Digoxin Drug Info Neomycin Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antiarrhythmic Agents Antibiotics
  Structure

 Mechanism of Digoxin-Neomycin Interaction (Severity Level: Minor)
     Altered absorption (Unspecific) Click to Show/Hide Mechanism Graph
      Drug Name Digoxin Neomycin
      Mechanism Absorption affected by oral aminoglycosides-induced malabsorption Malabsorption
      Key Mechanism Factor 1
Factor Name Pharmacokinetic
Factor Description Alters the absorption of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
      Mechanism Description
  • Altered absorption of Digoxin caused by Neomycin 

References
1 Lindenbaum J, Maulitz RM, Butler VP "Inhibition of digoxin absorption by neomycin." Gastroenterology 71 (1976): 399-404. [PMID: 950089]
2 Lindenbaum J, Tse-Eng D, Butler VP, Rund DG "Urinary excretion of reduced metabolites of digoxin." Am J Med 71 (1981): 67-74. [PMID: 7246583]
3 Rodin SM, Johnson BF "Pharmacokinetic interactions with digoxin." Clin Pharmacokinet 15 (1988): 227-44. [PMID: 3056649]