Drug General Information (ID: DDIPAENXBR)
Drug Name			Nizatidine		Drug Info		Raltegravir		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiulcer Agents				Antiviral Agents
Structure

Mechanism of Nizatidine-Raltegravir Interaction (Severity Level: Minor)
Altered gastric pH Click to Show/Hide Mechanism Graph
Drug Name		Nizatidine				Raltegravir
Mechanism		Gastric alkalinizer				Gastric pH sensitive
Key Mechanism Factor 1
		Factor Name		Gastric pH
		Factor Description		The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs.
Mechanism Description		Decreased absorption of Raltegravir due to altered gastric pH caused by Nizatidine

References
1	Product Information. Isentress (raltegravir). Merck & Company Inc, West Point, PA.