Details of Drug-Drug Interaction
| Drug General Information (ID: DDIP83WXHM) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Drug Name | Mycophenolate mofetil | Drug Info | Rabeprazole | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Immunosuppressive Agents | Antiulcer Agents | |||||||
| Structure | |||||||||
| Mechanism of Mycophenolate mofetil-Rabeprazole Interaction (Severity Level: Moderate) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Altered gastric pH Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Mycophenolate mofetil | Rabeprazole | |||||||
| Mechanism | Gastric pH sensitive | Gastric alkalinizer | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Gastric pH | ||||||||
| Factor Description | The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs. | ||||||||
| Mechanism Description |
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| Recommended Action | |||||||||
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| Management | Because clinical relevance of this interaction has not been established, proton pump inhibitors should be used with caution in transplant patients receiving mycophenolate mofetil. | ||||||||
| References | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Product Information. CellCept (mycophenolate mofetil). Roche Laboratories, Nutley, NJ. | ||||||||||||||||||
| 2 | Product Information. Myfortic (mycophenolic acid). Novartis Pharmaceuticals, East Hanover, NJ. | ||||||||||||||||||