Drug General Information (ID: DDIP4BETSV)
Drug Name			Gallium chloride Ga-67		Drug Info		Ferric derisomaltose		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Diagnostic Radiopharmaceuticals				Iron Supplement
Structure

Mechanism of Gallium chloride Ga-67-Ferric derisomaltose Interaction (Severity Level: Moderate)
Competitive binding of plasma proteins Click to Show/Hide Mechanism Graph
Drug Name		Gallium chloride Ga-67				Ferric derisomaltose
Mechanism		Competition for plasma protein binding sites				Competition for plasma protein binding sites
Key Mechanism Factor 1
		Factor Name		Plasma protein binding
		Factor Description		Plasma protein binding refers to the degree of binding of a drug to proteins in the blood, and the lower the degree of binding, the more efficiently the drug can cross cell membranes or diffuse. Plasma protein binding alters the distribution and therapeutic characteristics of the drugs.
Mechanism Description		Increased plasma concentration of Ferric derisomaltose and Gallium chloride Ga-67 due to competitive binding of plasma proteins

Recommended Action
Management		Clinicians should be aware of possible interference with diagnostic tests in patients who are taking these medications.

References
1	Product Information. Gallium Citrate Ga-67 (gallium citrate 67 Ga (gallium citrate 67Ga)). Bristol-Myers Squibb, Princeton, NJ.