Drug General Information (ID: DDIOWK4NJF)
Drug Name			Famotidine		Drug Info		Velpatasvir		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiulcer Agents				Antiviral Agents
Structure

Mechanism of Famotidine-Velpatasvir Interaction (Severity Level: Moderate)
Altered gastric pH Click to Show/Hide Mechanism Graph
Drug Name		Famotidine				Velpatasvir
Mechanism		Gastric alkalinizer				Gastric pH sensitive
Key Mechanism Factor 1
		Factor Name		Gastric pH
		Factor Description		The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs.
Mechanism Description		Decreased absorption of Velpatasvir due to altered gastric pH caused by Famotidine

Recommended Action
Management		H2-receptor antagonists may be administered simultaneously with or 12 hours apart from sofosbuvir-velpatasvir at a dose that does not exceed the equivalent of famotidine 40 mg twice daily.

References
1	Product Information. Epclusa (sofosbuvir-velpatasvir). Gilead Sciences, Foster City, CA.