Details of Drug-Drug Interaction
| Drug General Information (ID: DDIOWG2U9V) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Drug Name | Ranitidine | Drug Info | Lasmiditan | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Antiulcer Agents | Antimigraine Agents | |||||||
| Structure | |||||||||
| Mechanism of Ranitidine-Lasmiditan Interaction (Severity Level: Moderate) | |||||||||
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| Increased risk of bradycardia Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Ranitidine | Lasmiditan | |||||||
| Mechanism | Bradycardia | Bradycardia | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Bradycardia | ||||||||
| Factor Description | Bradycardia is a slow heart rate in which the heart beats less than 60 times per minute. If the heart rate is very slow and the heart is not pumping enough oxygen-rich blood to the body, and you may feel dizzy, very tired or weak, and short of breath. | ||||||||
| Mechanism Description |
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| Recommended Action | |||||||||
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| Management | Caution is advised during coadministration of lasmiditan and agents that lower heart rate if the estimated decrease in heart rate may present a clinical risk. Consider monitoring heart rate in patients for whom the estimated decrease in heart rate may not be tolerated. | ||||||||
| References | |||||||||||||||||||
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| 1 | Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN. | ||||||||||||||||||