Drug General Information (ID: DDIOSQH02E)
Drug Name			Oxtriphylline		Drug Info		Atracurium		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Bronchodilators				Neuromuscular Blocking Agents
Structure

Mechanism of Oxtriphylline-Atracurium Interaction (Severity Level: Moderate)
Antagonize the effect of neuromuscular blocking agents Click to Show/Hide Mechanism Graph
Drug Name		Oxtriphylline				Atracurium
Mechanism		Attenuates neuromuscular blockade				Neuromuscular blocking agent Neuronal acetylcholine receptor  Antagonist
Key Mechanism Factor 1
		Factor Name		Neuronal acetylcholine receptor				Structure Sequence
		Protein Family		Ligand-gated ion channel (TC 1.A.9) family
		Protein Function		After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.     Click to Show/Hide
Mechanism Description		Antagonize the effect of Oxtriphylline when combined with Atracurium

Recommended Action
Management		The patient should be monitored for adequate neuromuscular blockade and the dosage adjusted, if necessary.

References
1	Azar I, Kumar D, Betcher AM "Resistance to pancuronium in an asthmatic patient treated with aminophylline and steroids." Can Anaesth Soc J 29 (1982): 280-2
2	Daller JA, Erstad B, Rosado L, Otto C, Putnam CW "Aminophylline antagonizes the neuromuscular blockade of pancuronium but not vecuronium." Crit Care Med 19 (1991): 983-5
3	Doll DC, Rosenberg H "Antagonism of neuromuscular blockage by theophylline." Anesth Analg 58 (1979): 139-40