Drug General Information (ID: DDIOQ5BWDY)
Drug Name			Daptomycin		Drug Info		Fluvastatin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antibiotics				Statins/Antihyperlipidemic Agents
Structure

Mechanism of Daptomycin-Fluvastatin Interaction (Severity Level: Moderate)
Increased risk of other adverse reactions (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Daptomycin				Fluvastatin
Mechanism		Rhabdomyolysis				Rhabdomyolysis
Key Mechanism Factor 1
		Factor Name		Adverse reactions
		Factor Description		An adverse reaction is an unexpected negative reaction to a medication or treatment that happens even when it's used correctly.
Mechanism Description		Increased risk of adverse reactions by the combination of Daptomycin and Fluvastatin

Recommended Action
Management		Use of HMG-CoA reductase inhibitors should be temporarily suspended in patients receiving daptomycin. All patients receiving daptomycin should be monitored for the development of muscle pain or weakness, particularly of the distal extremities. CPK levels should be monitored weekly, and patients who develop unexplained elevations in CPK should be monitored more frequently. Daptomycin should be discontinued in patients with unexplained signs and symptoms of myopathy in conjunction with CPK levels exceeding 1000 U/L (approximately 5 times the upper limit of normal), or in patients without reported symptoms who have marked elevations in CPK (10 times the upper limit of normal, or more).

References
1	Product Information. Vytorin (ezetimibe-simvastatin). Merck &amp Company Inc, West Point, PA.
2	Product Information. Zocor (simvastatin). Merck &amp Co, Inc, West Point, PA.
3	Product Information. Cubicin (daptomycin). Cubist Pharmaceuticals Inc, Lexington, MA.