Drug General Information (ID: DDIOJ18HEP)
Drug Name			Iodine		Drug Info		Lithium carbonate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Nutritional Supplements				Antimanic Agents
Structure

Mechanism of Iodine-Lithium carbonate Interaction (Severity Level: Moderate)
Increased risk of other adverse reactions (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Iodine				Lithium carbonate
Mechanism		Hypothyroidism				Hypothyroidism
Key Mechanism Factor 1
		Factor Name		Adverse reactions
		Factor Description		An adverse reaction is an unexpected negative reaction to a medication or treatment that happens even when it's used correctly.
Mechanism Description		Increased risk of adverse reactions by the combination of Iodine and Lithium carbonate

Recommended Action
Management		Patients receiving iodides should be monitored for symptoms of hypothyroidism such as dry skin, weight gain, cold intolerance, weakness, muscle cramps or stiffness, slow pulse, or constipation.

References
1	Shopsin B, Shenkman L, Blum M, Hollander CS "Iodine and lithium-induced hypothyroidism. Documentation of synergism." Am J Med 55 (1973): 695-9. [PMID: 4749208]
2	Luby ED, Schwartz D, Rosenbaum H "Lithium-carbonate-induced myxedema." JAMA 218 (1971): 1298-9. [PMID: 5171179]
3	Wiener JD "Lithium carbonate-induced myxedema." JAMA 220 (1972): 587. [PMID: 4401588]