Drug General Information (ID: DDIOEZHSU7)
Drug Name			Sotalol		Drug Info		Astemizole		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiarrhythmic Agents				Antiallergic Agents
Structure

Mechanism of Sotalol-Astemizole Interaction (Severity Level: Major)
Increased risk of prolong QT interval Click to Show/Hide Mechanism Graph
Drug Name		Sotalol				Astemizole
Mechanism		Prolong QT interval				Prolong QT interval
Key Mechanism Factor 1
		Factor Name		QT interval
		Factor Description		Long QT syndrome is a heart signaling disorder that can cause a fast, chaotic heartbeat (arrhythmia). Many people may not exhibit symptoms, and usually the condition is detected during routine medical tests. In others, the most common symptoms include: sudden fainting, palpitations, dizziness, seizures, sudden death.
Mechanism Description		Increased risk of prolong QT interval by the combination of Sotalol and Astemizole

Recommended Action
Management		Alternate antihistamine therapy, such as cetirizine, fexofenadine or loratadine is recommended.

References
1	Feroze H, Suri R, Silverman DI "Torsades de pointes from terfenadine and sotalol given in combination." Pacing Clin Electrophysiol 19 (1996): 1519-21. [PMID: 8904547]