Drug General Information (ID: DDIO8M5RQL)
Drug Name			Valproic acid		Drug Info		Doripenem		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anticonvulsants				Carbapenems
Structure

Mechanism of Valproic acid-Doripenem Interaction (Severity Level: Major)
Antagonize the effect of antiepileptic agents Click to Show/Hide Mechanism Graph
Drug Name		Valproic acid				Doripenem
Mechanism		Antiepileptic agent				Lower seizure threshold
Key Mechanism Factor 1
		Factor Name		Antiepileptic agents
		Factor Description		The beneficial effects of antiepileptic drugs may be reduced, leading to an increase in seizure frequency or duration.
Mechanism Description		Antagonize the effect of Valproic acid when combined with Doripenem

Recommended Action
Management		Concomitant use of valproic acid with carbapenem antibiotics is generally not recommended. Use of alternative antibiotics should be considered in patients whose seizures are well controlled on valproic acid therapy. If coadministration is required, supplemental anticonvulsant therapy may be advisable, since increasing the valproic acid dose alone may not be sufficient to overcome the interaction. Nevertheless, pharmacologic response and serum valproate levels should be monitored closely following the addition or withdrawal of carbapenem treatment, and the dosage adjusted as necessary.

References
1	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA."
2	Molnar GP, Stephens KJ, George LV, Stewart JT "A critical interaction between ertapenem and valproic acid." J Clin Psychopharmacol 35 (2015): 348-50.[PMID: 25871574]
3	Tobin JK, Golightly LK, Kick SD, Jones MA "Valproic acid-carbapenem interaction: report of six cases and a review of the literature." Drug Metabol Drug Interact 24(2-4) (2009): 153-82.[PMID: 20408498]