Drug General Information (ID: DDIO5NGS4B)
Drug Name			Tazarotene (topical)		Drug Info		Isotretinoin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Dermatologic Agents				Antiacne Agents/Antineoplastics
Structure

Mechanism of Tazarotene (topical)-Isotretinoin Interaction (Severity Level: Moderate)
Increased risk of skin rash Click to Show/Hide Mechanism Graph
Drug Name		Tazarotene (topical)				Isotretinoin
Mechanism		Local skin irritation/drying				Local skin irritation/drying
Key Mechanism Factor 1
		Factor Name		Skin rash
		Factor Description		Skin rashes are the body's reaction to a certain drug. The type of rash that occurs depends on the drug that causes the rash and your reaction to it. Medications are associated with every type of rash, from mild to life-threatening. The timing of the rash may also vary.
Mechanism Description		Increased risk of skin rash by the combination of Tazarotene (topical) and Isotretinoin

Recommended Action
Management		Concurrent use should generally be avoided.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Pharmaceutical Society of Australia "APPGuide online. Australian prescription products guide online."